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Date: 8-9-2019
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Date: 28-10-2020
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Date: 8-9-2019
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Clemmensen Reduction
This alternative reduction involves heating a carbonyl compound with finely divided, amalgamated zinc. in a hydroxylic solvent (often an aqueous mixture) containing a mineral acid such as HCl. The mercury alloyed with the zinc does not participate in the reaction, it serves only to provide a clean active metal surface. The first example below shows a common application of this reduction, the conversion of a Friedel-Crafts acylation product to an alkyl side-chain. The second example illustrates the lability of functional substituents alpha to the carbonyl group. Substituents such as hydroxyl, alkoxyl & halogens are reduced first, the resulting unsubstituted aldehyde or ketone is then reduced to the parent hydrocarbon. A possible mechanism for the Clemmensen reduction will be displayed by clicking the "Show Mechanism" button.
Mechanisim
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الصحة العالمية: شركات التبغ تستهدف جيلا جديدا بهذه الحيل
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بكل عزيمة ونشاط.. كيف يمكن للطلبة مواجهة الامتحانات؟
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المجمع العلمي يُصدِر الكتاب الخامس من سلسلة (علماؤنا السابقون)
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