Conversion of Carboxylic acids to amide using DCC as an activating agent |
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date: 31-10-2019
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Date: 16-10-2020
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Date: 21-11-2019
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Date: 1-9-2019
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The direct conversion of a carboxylic acid to an amide is difficult because amines are basic and tend to convert carboxylic acids to their highly unreactive carboxylates. In this reaction the carboxylic acid adds to the DCC molecule to form a good leaving group which can then be displaced by an amine during nucleophilic substitution. DCC induced coupling to form an amide linkage is an important reaction in the synthesis of peptides.
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هل يمكن للدماغ البشري التنبؤ بالمستقبل أثناء النوم؟
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علماء: طول الأيام على الأرض يزداد بسبب النواة الداخلية
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أجواء صلاة عيد الأضحى المبارك من العتبة العسكرية المقدسة
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