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General applications

المؤلف:  Sue Jickells , Adam Negrusz (Editors)

المصدر:  Clarkes Analytical Forensic Toxicology

الجزء والصفحة:  364

2026-11-03

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General applications

Thousands of general and validated methods are available for the determination of drugs as pharmaceutical products and in biological fluids. Since the zone capacity of TLC systems is small, there are no general methods for drugs as a class, but there are a large number of methods for individual drugs defined by therapeutic or chemical categories. These still represent substantial diversity driven by the need to optimise selectivity for each group of substances taken for analysis. This information can provide a useful starting point for system selection, but is no general substitute for systematic method development. For these reasons universal methods for general drug analysis do not exist and earlier attempts at systematised approaches for different drug categories have failed to keep pace with the growth in number of drugs in those categories. In addition, systems recommended for the separation of individual drug categories rarely prove optimal for the separation of individual drugs and their impurities or metabolites.