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Liquid-filled capsules

المؤلف:  Sue Jickells , Adam Negrusz (Editors)

المصدر:  Clarkes Analytical Forensic Toxicology

الجزء والصفحة:  328

2026-10-29

32

Liquid-filled capsules

Soft gelatin capsules are commonly used to contain liquid or semi-liquid preparations (Fig 1). Some have abuse potential. Encapsulated liquid preparations of temazepam had to be modified and subsequently discontinued because the contents were being withdrawn with a syringe and needle and injected intravenously, intramuscularly or even intra-arterially, which caused severe lesions (Dodd et al.1994). Special two-piece hard gelatin capsules may be sealed for secure containment of liquids and semi-solids. The overlapping portion is moistened during the filling process and the cap and body effectively weld together as they dry. Two-piece capsules (Fig. 2) may be secured with a sealing band of shellac to prevent leakage of, or tampering with, the contents.

Figure 1 Soft gelatin capsule containing liquid. (Courtesy of TICTAC Communications Ltd.)

Figure 2 Cap and body capsule with sealing band. (Courtesy of TICTAC Communications Ltd.)