تسجيل الدخول

تسجيل

Rubella virus

المؤلف:  Baijayantimala Mishra

المصدر:  Textbook of Medical Virology

الجزء والصفحة:  2nd Edition , p193-194

2025-10-26

695

Rubella virus, now called Rubivirus rubellae is the only member of the genus Rubivirus, belong to the family Matonaviridae.

It is a single stranded, positive sense RNA virus. The shape is roughly spherical with a diameter of 50–85 nm. The genome is enclosed within the icosahedral capsid. The nucleocapsid is surrounded by an envelop. The genome consists of 9762 nucleotides and encodes three structural proteins (C, E1, E2) and two non-structural proteins (P90, P150) (Fig. 1).

Fig1. Rubella virus (schematic)

E1 and E2 are the two glycosylated lipoproteins present as transmembrane spikes on the envelop. E1 which is the major antigenic determinant, induces humoral antibody response. The antibody titer against this protein correlates with the level of protection. E1 protein is also responsible for binding to the host cell receptor myelin oligodendrocytes glycoprotein (MOG) and receptor-mediated endocytosis. E2 protein is embedded to the envelop and forms connections between the rows of E1 proteins.

The two non-structural proteins are responsible for viral replication.