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Date: 28-6-2019
1754
Date: 31-5-2016
3610
Date: 27-10-2019
967
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Often during the synthesis of complex molecules on functional group in a molecule interferes with an intended reaction on a second functional group on the same molecule. An excellent example is the fact that a Grignard reagent can't be prepared from halo alcohol because the C-Mg bond is not compatible with the acidic -OH group.
When situations like this occurs chemists circumvent eh problem by protecting the interfering functional group. Functional group protection involves three steps:
There are several methods for protecting an alcohol, however, the most common is the reaction with a chlorotrialkylsilane, Cl-SiR3 This reactions forms a trialkylsilyl ether, R'-O-SiR3. Chlorotrimethylsilane is often used in conjuction with a base, such as triethylamine, The base helps to form the alkoxide anion and remove the HCl produced by the reaction.
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حمية العقل.. نظام صحي لإطالة شباب دماغك
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إيرباص تكشف عن نموذج تجريبي من نصف طائرة ونصف هليكوبتر
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