Special Gels for Drug Release

Metyjaszewski et al. reported [39] preparation of nanostructured hybrid hydrogels for tissue engineering and drug delivery applications. They incorporate poly (oligo (ethylene oxide) monomethyl ether methacrylate) nanogels of size 100–200 nm into a larger 3D matrix, such as hyaluronic acid gel. The macroscopic hydrogel acts as a 3D matrix regulator for the drug release. In this work, polymerizable poly (oligo (ethylene oxide) monomethyl ether methacrylate) nanogels were covalently incorporated into a 3D network via a photo-polymerization process. The introduction of disulfide moieties into the polymerizable groups resulted in releasable nanogels from cross-linked 3D network under reducing environment. Tan, Fu, and coworkers [40] reported preparation of a pH-sensitive biodegradable polyurethane for drug release:

A series of pH-sensitive polyurethanes were synthesized using pH-sensitive macrodiol, shown above, and a tripeptide chain extender. The obtained polyurethane had a number average molecular weight of 4,500–6,200. The material cleaves in acid media (pH 4–6) and degrades in enzymatic solution. McCormick and coworkers [41] reported the synthesis of a temperature-responsive triblock copolymer, consisting of a-methoxy propyl (ethylene oxide)-b-poly(N-(3-aminopropyl) metha cryIamide)-b-poly(N-isopropylacrylamide). At room temperature, the polymer is hydrophilic and exists as individual molecule in aqueous solution. Increasing the solution temperature above a lower critical solution temperature leads to self-assembly into micelles. The PAPMA portions were cross linked with terephthaldicarboxaldehyde at pH 9.0 to generate shell cross-linked micelles with cleavable imine linkages. The release of a model hydrophobic drug, prednisolone 21-acetate, was studied at specific pH and temperature conditions. The drug was released at pH 6.0 as hydrolytic cleavage of the imine cross-links within the swollen micelles occurred.

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قسم شؤون المعارف يستقبل وفدًا أكاديميًّا لتعزيز التعاون العلمي المشترك

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نصائح علمية لتقوية دماغك وتقليل التدهور العقلي

هرمون الذكورة يفاقم عدوى خطيرة تهدد حياة الرجال

سبب رئيسي للإصابة بسرطان القولون

بعد سن الأربعين.. هل أنت من الفئات المعرضة لخطر الغلوكوما؟

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حرق الأمونيا.. كيف يساعد محطات الكهرباء في اليابان على إزالة الكربون؟

الشمس تقذف نتوءا عملاقا باتجاه قطبها الشمالي

كيف يخدع النعناع جسمك ليشعر بالبرودة؟.. صور عالية الدقة تكشف السر لأول مرة

ما الدور الذي يلعبه الـ AI في "حروب أميركا"؟

المزيد

مواضيع ذات صلة

Immobilized Nonenzymatic Catalysts

Immobilized Catalysts

Support Materials Other Than Polystyrene

Materials Based on Polystyrene

Polymer Supports for Reagents, Catalysts, and Drug Release

Degradation of Polymeric Materials by Ionizing Radiation

Oxidation of Chain-Growth Polymers

Oxidative Degradation of Polymers

Thermal Degradation of Cellulosic Materials

Thermal Degradation of Polyimides, Polyoxidiazoles, and Polyquinoxalines

Thermal Degradation of Aromatic Polysulfones

Thermal Degradation of Epoxy Resins